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Establishing outcome measures in early knee osteoarthritis

Emery, Carolyn A (author)
University of Calgary
Whittaker, Jackie L (author)
University of Alberta
Mahmoudian, Armaghan (author)
University Hospitals Leuven
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Lohmander, L Stefan (author)
Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund OsteoArthritis Division - Nedbrytning av ledbrosk: en biologisk process som leder till artros,Forskargrupper vid Lunds universitet,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund OsteoArthritis Division - Molecular marker research group,Lund University Research Groups,Skåne University Hospital
Roos, Ewa M (author)
University of Southern Denmark
Bennell, Kim L (author)
University of Melbourne
Toomey, Clodagh M (author)
University of Calgary
Reimer, Raylene A (author)
University of Calgary
Thompson, Dylan (author)
University of Bath
Ronsky, Janet L (author)
University of Calgary
Kuntze, Gregor (author)
University of Calgary
Lloyd, David G (author)
Griffith University
Andriacchi, Thomas (author)
VA Palo Alto Health Care System
Englund, Martin (author)
Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund OsteoArthritis Division - Clinical Epidemiology Unit,Forskargrupper vid Lunds universitet,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
Kraus, Virginia B (author)
Duke University
Losina, Elena (author)
Brigham and Women's Hospital / Harvard Medical School,Boston University,Harvard University
Bierma-Zeinstra, Sita (author)
Erasmus University Medical Center
Runhaar, Jos (author)
Erasmus University Medical Center
Peat, George (author)
Keele University
Luyten, Frank P (author)
University Hospitals Leuven
Snyder-Mackler, Lynn (author)
University of Delaware
Risberg, May Arna (author)
Oslo university hospital
Mobasheri, Ali (author)
Queen's Medical Centre, Nottingham
Guermazi, Ali (author)
Boston University
Hunter, David J (author)
Royal North Shore Hospital,University of Sydney
Arden, Nigel K (author)
Oxford Brookes University
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 (creator_code:org_t)
2019-06-14
2019
English.
In: Nature Reviews Rheumatology. - : Springer Science and Business Media LLC. - 1759-4804 .- 1759-4790. ; 15:7, s. 438-448
  • Research review (peer-reviewed)
Abstract Subject headings
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  • The classification and monitoring of individuals with early knee osteoarthritis (OA) are important considerations for the design and evaluation of therapeutic interventions and require the identification of appropriate outcome measures. Potential outcome domains to assess for early OA include patient-reported outcomes (such as pain, function and quality of life), features of clinical examination (such as joint line tenderness and crepitus), objective measures of physical function, levels of physical activity, features of imaging modalities (such as of magnetic resonance imaging) and biochemical markers in body fluid. Patient characteristics such as adiposity and biomechanics of the knee could also have relevance to the assessment of early OA. Importantly, research is needed to enable the selection of outcome measures that are feasible, reliable and validated in individuals at risk of knee OA or with early knee OA. In this Perspectives article, potential outcome measures for early symptomatic knee OA are discussed, including those measures that could be of use in clinical practice and/or the research setting.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Ortopedi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Orthopaedics (hsv//eng)

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